== Access to BIOS data == There are two ways to access BIOS data: === 1. Download of selected data through EGA === RNA-seq, DNA methylation, sex, age and cell count data that has been analyzed in publications can be requested and downloaded from The European Genome-phenome Archive (EGA). The advantage is that data can be downloaded to own computational facilities, but not all data can be accessed (e.g. SNPs). [http://www.bbmri.nl/wp-content/uploads/2015/10/BIOS_DATA_ACCESS_POLICY_CONDITIONS_v4.docx Click here] to download the document for BIOS data requests through EGA. The document includes the data sharing policies. === 2. Analyze all data on a centralized computational facility === For BBMRI-NL researchers, all data shared by participating biobanks including genome-wide SNP data, limited phenotypes, RNA-seq and DNA methylation on all individuals can be analyzed on centralized computational facilities, namely the !LifeScience Grid and the SurfSARA High Performance Computing cloud (https://userinfo.surfsara.nl/systems/grid/new-users). The advantage of this approach is that all available data can be analyzed (including those with a privacy aspect), but the data cannot be downloaded and a relatively strict security protocol has to be adopted. Please, fill out this [http://www.bbmri.nl/wp-content/uploads/2015/10/BIOSdataaccessrequest.doc form] if you wish to request access to BIOS data at the SurfSARA servers. To complete this request, you will also need to sign the [http://www.bbmri.nl/wp-content/uploads/2015/10/BIOSCodeOfConduct.pdf BIOS Code Of Conduct]. [http://www.bbmri.nl/wp-content/uploads/2015/10/BIOSrequestsoverview2015-Sep.pdf Click here] for an overview of current data requests. == Publications acknowledging BIOS == Latest update: [http://www.bbmri.nl/wp-content/uploads/2015/10/BIOSpapersacknowledging.pdf September 2015] === Management team === Bastiaan T. Heijmans (chair)^1^, Peter A.C. ’t Hoen^2^, Joyce van Meurs^3^, Rick Jansen^5^, Lude Franke^6^. === Cohort collection === Dorret I. Boomsma^7^, René Pool^7^, Jenny van Dongen^7^, Jouke J. Hottenga^7^ (Netherlands Twin Register); Marleen MJ van Greevenbroek^8^, Coen D.A. Stehouwer^8^, Carla J.H. van der Kallen^8^, Casper G. Schalkwijk^8^ (Cohort study on Diabetes and Atherosclerosis Maastricht); Cisca Wijmenga^6^, Lude Franke^6^, Sasha Zhernakova^6^, Ettje F. Tigchelaar^6^ (!LifeLines Deep); P. Eline Slagboom^1^, Marian Beekman^1^, Joris Deelen^1^, Diana van Heemst^9^ (Leiden Longevity Study); Jan H. Veldink10, Leonard H. van den Berg10(Prospective ALS Study Netherlands); Cornelia M. van Duijn4, Bert A. Hofman11, Aaron Isaacs4, André G. Uitterlinden3 (Rotterdam Study). === Data Generation === Joyce van Meurs (Chair)^3^, P. Mila Jhamai^3^, Michael Verbiest^3^, H. Eka D. Suchiman^1^, Marijn Verkerk^3^, Ruud van der Breggen^1^, Jeroen van Rooij^3^, Nico Lakenberg^1^. === Data management and computational infrastructure === Hailiang Mei (Chair)^12^, Maarten van Iterson^1^, Michiel van Galen^2^, Jan Bot^13^, Dasha V. Zhernakova^6^, Rick Jansen^5^, Peter van ’t Hof^12^, Patrick Deelen^6^, Irene Nooren^13^, Peter A.C. ’t Hoen^2^, Bastiaan T. Heijmans^1^, Matthijs Moed^1^. === Data Analysis Group === Lude Franke (Co-Chair)^6^, Martijn Vermaat^2^, Dasha V. Zhernakova^6^, René Luijk^1^, Marc Jan Bonder^6^, Maarten van Iterson^1^, Patrick Deelen^6^, Freerk van Dijk^14^, Michiel van Galen^2^, Wibowo Arindrarto^12^, Szymon M. Kielbasa^15^, Morris A. Swertz^14^, Erik. W van Zwet^15^, Rick Jansen^5^, Peter-Bram ’t Hoen (Co-Chair)^2^, Bastiaan T. Heijmans (Co-Chair)^1^.[[BR]] 1. Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands 2. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands 3. Department of Internal Medicine, ErasmusMC, Rotterdam, The Netherlands 4. Department of Genetic Epidemiology, ErasmusMC, Rotterdam, The Netherlands 5. Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands 6. Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands 7. Department of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, The Netherlands 8. Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands 9. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands 10. Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands 11. Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands 12. Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands 13. SURFsara, Amsterdam, the Netherlands 14. Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands 15. Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands